C1 Esterase Inhibitor (aka C1 Inhibitor & C1INH)

Department of Immunology

Notes

• Immunochemical C1 esterase inhibitor is assessed along with complement C3 and C4. If low then a functional assay will also be performed.
• Low levels are seen in hereditary angioedema, which is an autosomal dominant disorder. Acquired C1 inhibitor deficiency may also occur in B-cell lymphomas and some autoimmune diseases.
• Test performed at Southmead Hospital, Bristol.
• Specimen must arrive in the laboratory within 2 hours of collection.
  

Sample Requirements

Clotted blood.

Adult

5 mL Gold-top SST tube or 3.5 mL Rust-top gel tube (Trust users only)

Paediatric

1ml Serum Sample

Specimen must arrive in the laboratory within 2 hours of collection.

Time limit for add-on

Not appropriate as an add-on test due to the labile nature of this analyte.

Turnaround Times

21 Days

Reference Ranges