Caeruloplasmin
Chemical Pathology
Background Information
- Caeruloplasmin is the major protein bound form of copper in the circulation.
- Caeruloplasmin levels may be low in Wilson's disease, or in rare acquired copper deficiency states (e.g. excessive zinc intake, persistent infantile diarrhoea, severe malabsorption or nephrotic syndrome).
- For investigation of possible Wilson's disease, the GHNHST Gastroenterology protocol for abnormal LFT's only recommends caeruloplasmin measurement in patients under 50 years of age who have persistently raised ALT.
- Caeruloplasmin is an acute phase protein and is therefore often elevated in infection and inflammation, samples may therefore not be processed if there is evidence of inflammation (indicated by a raised CRP result).
- Pregnancy, OCP and oestradiol containing medications may also increase caeruloplasmin levels.
- 24 hour urine copper measurement is an alternative screening test for Wilson's Disease.
Patient Preparation
- No specific preparation required.
Sample Requirements
For adults, blood taken into a 5mL gold top tube (or rust top for the Acute Unit)

For children, blood taken into a 3.5mL rust top tube

Storage/Transport
Do not store. Send at ambient temperature to the laboratory the same day.
Required Information
Relevant clinical details and a recent CRP level.
Turnaround times
Samples are referred to an external laboratory for analysis with results expected back within 9 working days.
Reference ranges
Ranges and interpretation reported as provided by referral laboratory.
Further information
To learn more about caeruloplasmin visit Lab Tests Online: Caeruloplasmin
Page last updated: 19/09/2025 | Page last reviewed: 19/09/2025