Glomerular Basement Membrane Antibodies

Department of Immunology

Notes

• Glomerular basement membrane (GBM) antibodies are a highly sensitive and specific marker of Goodpasture's syndrome.
• Indications include unexplained renal/lung disease (pulmonary renal syndrome) and rapidly progressive glomerulonephritis. The diagnosis can be confirmed by renal biopsy immunofluorescence, which detects the same autoantibodies in situ.
• Tests are performed at the Immunology Department, Southmead Hospital.

Sample Requirements

Clotted blood. (No patient preparation or special handling required)

Adult

5ml Gold-top SST tube or 3.5ml Rust-top gel tube (Trust users only)

Paediatric

1ml Serum Sample

Turnaround Times

1 week

Time Limit for Add-ons

3 days

Reference Range