Chemical Pathology

Notes

Insulin-like growth factor-1 (IGF-1) in the circulation originates mainly from the liver under control of pituitary growth hormone (GH). Levels of IGF-1 parallel those of GH.

IGF-1 levels are therefore indicated in the:

  • diagnosis and treatment monitoring of GH secreting tumours
  • Investigation of short stature in children
  • investigation of suspected pituitary insufficiency

Sample requirements

For adults, blood taken into a 5mL gold top tube (or rust top for the Acute Unit)

5ml gold tube





For children, blood taken into a 3.5mL rust top tube

3.5ml rust top tube





For neonates, blood taken into a 1mL minicollect plain tube

1ml serum tube


Storage/transport

Do not store. Send at ambient temperature to the laboratory on the day of sample collection.

Required information

Relevant clinical details including reason for the request.

Turnaround times

The samples are analysed once a week.

Reference ranges

Age (years) Female (nmol/L) Male (nmol/L)
0 – 2 2.2 – 12.8 1.6 – 12.5
3 – 5 5.7 – 24.2 3.5 – 17.6
6 – 9 10.6 – 40.0 8.2 – 30.8
10 14.7 – 52.1 11.2 – 44.9
11 16.1 – 55.9 12.3 – 51.4
12 17.3 – 59.1 13.2 – 56.9
13 18.3 – 61.3 14.1 – 61.2
14 19.1 – 62.9 15.1 – 64.1
15 19.8 – 63.5 15.7 – 65.6
16 20.2 – 63.5 16.4 – 65.9
17 20.4 – 62.7 16.9 – 64.8
18 20.4 – 61.0 17.3 – 62.4
19 20.3 – 58.8 17.6 – 59 .0
20 19.9 – 56.2 17.8 – 55.2
21 – 25 18.1 – 49.1 17.8 – 45.6
26 – 30 15.5 – 39.7 16.4 – 35.5
31 – 35 13.6 – 33.4 14.9 – 32.4
36 – 40 12.4 – 30.3 13.5 – 30.7
41 – 45 11.3 – 29.1 12.1 – 29.0
46 – 50 10.3 – 28.6 10.8 – 27.4
51 – 55 9.4 – 27.5 9.5 – 26.2
56 – 60 8.5 – 25.4 8.3 – 25.3
61 – 65 7.6 – 23.1 7.7 – 24.6
66 – 70 7.1 – 21.5 7.3 – 24.2
71 and above 7.0 – 21.0 6.9 – 24.1

Note: levels of IGF-1 may be low with anorexia or malnutrition.

Further information

To learn more about IGF-1 visit Lab Tests Online

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