IgG Tissue Transglutaminase

Department of Immunology

Notes

• This is a reflex test added by the laboratory when an IgA TTG indicates the patient has low total IgA level. It is referred to Immunology at North Bristol trust
• IgG TTG has a widely variable clinical sensitivity so a negative result does not reliably exclude Coeliac disease. If there is a high clinical suspicion, then consideration should be given to referring to Gastroenterology for further investigations.
• A positive IgG TTG is insufficient in isolation to make a diagnosis of Coeliac disease; such patients should be referred to Gastroenterology for further investigations.
• Serial monitoring is not recommended as the relationship between antibody level and coeliac disease activity and or dietary compliance is uncertain.

Sample Requirements

(No patient preparation or special handling required).

Adult

5ml Gold-top SST tube or 3.5ml Rust-top gel tube (Trust users only)

Paediatric

1ml Serum Sample

Turnaround Times

16 days