Teicoplanin assay
Microbiology
Notes
- These tests are referred to a Regional Reference Centre
- Teicoplanin levels are non-urgent investigations and efforts should be made to avoid routine testing (and sampling) at weekends.
- If necessary, assays can be arranged for Saturday mornings and most Bank Holidays, but must be received by the Microbiology Department at GRH by 10.00 am. Please telephone the laboratory to inform us that such a sample has been taken, requires testing and to confirm transport arrangements for the sample to the Microbiology Department at GRH
- There is no service available on Sundays
When to test
- The initial pre-dose assay sample should be collected just before the dose given on the 5th day. If this falls on a Sunday, the sample can be taken as planned and should be sent to Pathology Specimen Reception on the Sunday for dispatch for testing on the next working day
- If a patient is on a prolonged course of teicoplanin (>2 weeks) and the initial levels are satisfactory, repeat levels should be monitored weekly
- Otherwise, the Consultant Microbiologist will advise on repeat sampling, if indicated
Result interpretation
- Results are reported with a standard interpretative comment that gives the recommended target (normal) levels
- If there is any doubt regarding interpretation, contact the Consultant Microbiologist.
Normal levels:
| Indication | Respiratory, Cellulitis, Neutropenic Sepsis and Unknown Source Infections | Bone and Joint Infections | Infective Endocarditis |
|---|---|---|---|
| Levels (Trough - prior to dose) | |||
| When | Day 5 | Day 5 | Day 5 |
| Target Range | 15-60mg/L | 20-60mg/L | 30-60mg/L |
| Repeat | Weekly unless advised otherwise | Weekly unless advised otherwise | Weekly unless advised otherwise |
Sample Requirements
Serum
Samples must NOT be taken via lines
8.5ml of blood taken into a plain gel tube
Storage/transport
Store at fridge temperature
Transport as soon as possible at ambient temperature
Required information
Relevant clinical details
Turnaround time
Sent to a Regional Reference Centre
Results usually available within 36 hours
Results will be entered onto the laboratory computer system and reported as soon as practicable – these will be available electronically using "Pathology Enquiry".