Please note: this test is only requestable by the endocrine consultants at GHNHSFT
11 deoxycortisol may be indicated in the diagnosis and monitoring of congenital adrenal hypoplasia (CAH) due to 11ß-hydroxylase deficiency. This is an autosomal recessive disorder causing about 5-8% of cases of CAH and resulting in androgen excess, virilisation and hypertension.
The test may be requested when CAH is suspected on clinical grounds but serum 17-OH progesterone levels are equivocal, however this test has largely been superceded by urine steroid profiling and is therefore rarely required. Please telephone the duty biochemist with any queries.
- Samples are best collected early morning.
For adults, blood taken into a 5mL gold top tube (or rust top for the Acute Unit)
For children, blood taken into a 3.5mL rust top tube
For neonates (>48 hours old), blood taken into a 1.0mL plain minicollect tube
Do not store. Send at ambient temperature to the laboratory on the day of sample collection.
Relevant clinical details are required when requesting this test.
The samples are sent for analysis to Guy's and St Thomas' Hospital London, with results expected back within 2 weeks.
If results are needed more quickly on clinical grounds then the healthcare professional should contact the duty biochemist before taking the sample.
Adult reference range 0.7 – 2.7 nmol/L.
No specific paediatric reference range quoted, however each result will have interpretative comments.
To learn more visit Patient.co.uk resources on CAH
Page last updated: 20/04/2021