Coagulation Time-Dependant Inhibitor Screen
Department of Haematology
- This test is only performed following discussion with the Consultant Haematologist.
- Inhibitors affecting the APTT may act immediately or be time dependent. Normal plasma mixed with plasma containing a time dependent inhibitor will initially have a corrected APTT clotting time. However, after 1-2 hours the correction will be overcome and the clotting time will again become prolonged.
- In elderly patients the detection of an unexplained low Factor VIII result in conjunction with a corrected APTT with normal plasma is unlikely to be a result of undiagnosed Haemophilia A or von Willebrands Disease. It is more likely to be due to the presence of a spontaneously produced Factor VIII inhibitor.
- Severe Haemophiliacs can produce inhibitors to the Factor VIII treatment they are receiving so should be screened for inhibitors periodically.
- Test performed at CGH and GRH.
3 or 3.5ml Trisodium Citrate tube
N/A. The presence or absence of a time-dependant inhibitor will be indicated.
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