Neonatal alloimmune neutropenia (NAIN)
Neonatal alloimmune neutropenia (NAIN) is a transient disorder characterised by maternal IgG antibodies targeting fetal neutrophil antigens, resulting in neutropenia. This condition arises when the fetus inherits neutrophil-specific antigens from the father that are absent in the mother. Maternal sensitisation leads to the production of alloantibodies, which cross the placenta and mediate neutrophil destruction.
Blood Transfusion
Notes
- Requires Consultant Haematologist approval
- Histocompatibility & Immunogenetics Granulocyte Immunology 3E required to request this test (form available from Transfusion laboratory or available using the link below)
- This test is performed at NHSBT Filton, Bristol
H&I Request Form (3E) - Granulocyte Immunology
Sample Requirements
Maternal EDTA tube - 6mL
Maternal Serum tube - 6mL
Paternal EDTA tube - 6mL
Neonate EDTA tube - 1mL
Required Information
For neonate sample 1mL EDTA sample if possible.
Sample and request form must be labelled correctly with 4 points of reference:
- Forename
- Surname
- Date of birth
- NHS No.
The sample tube(s) must be signed and dated by the person taking the blood.
The NHSBT may decline to test inadequately labelled samples.
For further information on specimen labelling refer to the H&I 3E Platelet Immunology request form
Turnaround time
Up to 21 working days
Author: Stuart Lord, Lead Transfusion Practitioner
Reviewed date: 22/04/2025
Next review date: 22/04/2027