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The Biophotonics Research Unit's goals are to pioneer the field of novel optical diagnostics within the clinical environment.
The Biophotonics Research Unit
We lead research into vibrational spectroscopy (Raman and FT-IR), diagnostics for in vivo and in vitro discrimination of early cancers, degenerative diseases and local and systemic disease studies in body fluids.
We also work in the following areas:
- mid-IR hyperspectral imaging of tissues for pathological diagnostics and biochemical analysis
- optical coherence tomography for real-time surgical targeting of disease and biopsy selection
- photodynamic therapy for early cancers and dysplasia
- volatile analysis techniques for detection of infections.
Professor Hugh Barr and his team were shortlisted for again for the BMJ Awards Cancer Care Team category 2017.
RAFTER (RAman For Thyroid cancER)
RAFTER is a project funded by Cheltenham and Gloucester Hospitals Charity through FOCUS with generous donations from Gloucestershire Cricket and crowd funding. Its aims to develop a rapid, minimally invasive diagnosis technique for swollen thyroid glands, to improve the screening process by avoiding the need for an invasive surgical biopsy. Many patients experience weakness of their vocal cords following surgery, but this less invasive approach to diagnosis will have little if any side effects. Using specially developed fibre-optic probes which can target tissue below the skin, we can tell the difference between healthy and cancerous tissue by measuring light from tissue when illuminated by a low-power laser; a technique called Raman spectroscopy.
GALAHAD (Glaucoma – Advanced, LAbel-free High resolution Automated OCT Diagnostics)
GALAHAD is a project funded by the EC through Horizon 2020. Its primary objective is to improve screening and basic diagnostics for glaucoma, which is a major cause of blindness throughout the world. The project brings together ten partners: four industrial, three academic, two clinical and one management
RaPIDE (RAman Probe for In vivo Diagnostics (during oesophageal) Endoscopy)
RaPIDE seeks to develop a miniaturised probe that slides down the working channel of an endoscope, to diagnose oesophageal cancer using Raman spectroscopy without the need for an invasive, expensive and distressing biopsy.
The project is a collaboration between The Biophotonics Research Unit and Biomedical Spectroscopy Group at The University of Exeter, and Interface Analysis Centre at The University of Bristol.
The Raman4Clinics project pools European expertise to step forward the field of novel, label-free and rapid technologies, based on a wide variety of Raman spectroscopies for the clinical diagnostics of body fluids, bacteria, cells and tissues. The goal is to give a major impetus in this vibrant field of research by aligning our techniques to clinical requirements and application aspects (the unmet medical need)
Laser and Intense Light Sources Safety Course
The unit runs a BMLA-approved course twice a year, around May and November. This course covers the recommended syllabus in “Guidance on the safe user of lasers, intense light source systems and LEDs in medical, surgical, dental and aesthetic practices” – DB2008(03), April 2008 (Medical and Healthcare Products Regulatory Agency – ‘Core of Knowledge’)
Our next course is on 21/11/2018 at Kingsholm Stadium, Gloucester.
For further information, or to book onto one of our courses, please contact Allison
To contact the team, email: ghn-tr.Biophotonics-Team@nhs.net