EBV (glandular fever) antibodies (mononucleosis)

Microbiology

Notes

• The information given here is intended for use by healthcare professionals. Please see Lab Tests Online-UK for more general advice, links and background.
• This investigation is used to diagnose Epstein Barr Virus infection
• The investigation comprises three tests:
  • EBVNA IgG
  • EBV VCA IgG
  • EBV IgM
• A positive EBVNA IgG result indicates infection more than six weeks previously
• A positive EBV VCA IgG result indicates infection at some time
• An EBV IgM is performed on all children under 16 years
• EBV viral loads are useful for the diagnosis of active EBV infection in immuno-compromised patients, including PTLD (see EBV viral load)
• This test is part of the following viral screen sets:
  • Hepatitis screen - acute
  • Glands screen
  • Malaise screen - acute (EBVNA IgG only)
  • Chronic malaise screen
• See also Throat swab

Sample requirements

Serum - paired samples not required

8.5ml of blood taken into a plain gel tube

Required information

• Relevant clinical details
• Date of onset
• Jaundice, abnormal LFTs
• Lymphadenopathy, malaise, myalgia, flu-like illness
• Glandular Fever

Storage/transport

Store at fridge temperature

Transport as soon as possible at ambient temperature

Turnaround time

7 - 10 days