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In both cases, ultra-large vWF multimers build up in the blood stream.
NB if unable to distinguish between passive and immune anti-D, FMH estimation should be performed.
Reference ranges Serum/plasma total calcium: 2.20–2.63 mmol/L (NB: apparently raised total calcium levels up to 3.00 mmol/L in 0–3 month infants and up
The dose of metformin should be built up slowly by 500mg increments per week to minimise GI side effects.
Add-on treatment for angina where heart rate or blood pressure prevents up-titration of other agents.