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You can reduce the risk by: being more physically active trying to achieve a healthy weight (BMI 18.5kg/m2 to 25kg/m2) maintaining a healthy diet breastfeeding
NICE recommends that the dose should be reviewed if eGFR less than 45 mL/minute/1.73 m2 and to avoid if eGFR less than 30 mL/minute/1.73 m2.