Abatacept is a fusion protein that consists of the extracellular domain of human cytotoxic T-lymphocyte-associated antigen 4 (CTL1-4) linked to a modified Fc portion of human immunoglobulin G1 (IgG1).

It is from a group of drugs called cytokine inhibitors. Cytokines are small protein molecules, which occur in the body and are involved in inflammatory conditions. Abatacept modulates the T lymphocyte response, reducing inflammation through effects on cytokines such as TNF alpha, interferon and interleukin-2.

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